Nervous system dysregulation is just one piece of the puzzle, but it’s a commonly overlooked factor that can play a huge role in persistent fatigue. Here are some other reasons fatigue might be lingering:

→ Ongoing Inflammation and Immune System Activation
If your body is fighting off a chronic condition, it can cause inflammation, which in turn requires a lot of energy. This immune response can feel like running a full-time marathon even when you’re resting.

→ Nutrient Deficiencies or Poor Absorption
Even if you’re eating a balanced diet, chronic illness or stress can affect how well you absorb essential nutrients. This can contribute to fatigue, as your body may be lacking the fuel it needs for energy production.

→ Hormonal Imbalances
When your body is under constant stress or dealing with chronic illness, it can throw your hormones out of balance. Cortisol, often called the “stress hormone,” can remain elevated, leading to persistent fatigue and energy crashes. Over time, this stress can also affect other hormones that regulate sleep, mood, and your body’s ability to recover.

Other Potential Contributors to Fatigue